Anti-Human CD38 Monoclonal Antibody(Isatuximab)

僅用于工業(yè)應(yīng)用或科學(xué)研究，不可用于人類或動(dòng)物的臨床診斷或治療，非藥用. Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma （MM）. Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions